陆瑶，博士，研究员，博士生导师
电话：0411-84379390
邮箱：luyao@dicp.ac.cn
个人主页网址：https://people.ucas.ac.cn/~dicpluyao
简历介绍：
2003年毕业于安徽大学，获理学学士学位；2010年毕业于中国科学院大连化学物理研究所，获得分析化学专业博士学位；2010-2015年在美国耶鲁大学生物医学工程系从事博士后研究，2015年回国工作至今，2021年晋升为研究员。长期聚焦微流控芯片与单细胞分析技术前沿，面向国家精准医学与免疫/细胞治疗战略需求，围绕细胞功能高通量、可解释测量的关键瓶颈开展技术攻关，在关键共性平台与自主可控工具体系方面形成系统创新。相关工作发表于PNAS, Nature Communications, Science Signaling等期刊，研究论文单篇最高他引800+次（Google scholar）；共同主编中文、英文专著各一部。主持包括国家自然科学基金（4项）、国家重点研发计划课题、人社部留学人员科技项目择优资助、大连化物所创新基金等科研项目十余项，入选国家万人计划青年拔尖人才、中国科学院青年创新促进会优秀会员、辽宁省自然科学基金青年基金项目（A类）等人才项目。作为主要发明人发展的单细胞分泌蛋白分析技术实现转化（美国Bruker公司），被全球100余家制药公司（包括世界top15的所有药企）及肿瘤中心采用，帮助肿瘤免疫/细胞治疗药物开发与临床测试，被美国著名科普杂志《科学家》（The Scientist）评选为2017年度十大医疗技术发明首位。
研究方向：
1. 高通量单细胞分泌分析多组学技术发展及其生物医学应用；
2. 面向细胞治疗、中药现代化的药物分析；
3. 微流控数字液滴中央处理器；
4. 基于微流控芯片的高通量、快速、高灵敏分析。
代表性成果：
1. Yao Lu#, Qiong Xue#, Markus Eisele, Endah Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe’er, Kathryn Miller-Jensen* & Rong Fan*, Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands. PNAS, 2015, 112 (7), E607-E615.
2. Yahui Ji, Dongyuan Qi, Linmei Li, Haoran Su, Xiaojie Li, Yong Luo, Bo Sun, Fuyin Zhang, Bingcheng Lin, Tingjiao Liu*, Yao Lu*, Multiplexed Profiling of Single-cell Extracellular Vesicles Secretion. PNAS, 2019, 116 (13):5979-5984.
3. Jiu Deng, Yahui Ji, Fengjiao Zhu, Lina Liu, Linmei Li, Xue Bai, Huibing Li, Xianming Liu, Yong Luo, Bingcheng Lin, and Yao Lu*, Mapping secretome-mediated interaction between paired neuron-macrophage single-cells, PNAS, 2022,119(44): e2200944119.
4. Linmei Li#, Haoran Su#, Yahui Ji, Fengjiao Zhu, Jiu Deng, Xue Bai, Huibing Li, Xianming Liu, Yong Luo, Bingcheng Lin, Tingjiao Liu*, Yao Lu*, Deciphering cell-cell interactions with integrative single-cell secretion profiling, Advanced Science，2023: 2301018.
5. Zhuo Chen#, Yao Lu#*, Kerou Zhang, Yang Xiao, Jun Lu, Rong Fan*, Multiplexed, sequential secretion analysis of the same single cells reveals distinct effector response dynamics dependent on the initial basal state. Advanced Science, 2019, 6(9):1801361. (Highlighted as Inside Cover)
6. Fengjiao Zhu, Yangyang Long, Weiwei Shi, Bin Li, Yahui Ji, Xue Bai, Xianming Liu, Dongyuan Qi, Bo Sun, Fuyin Zhang, Tingjiao Liu, Bingcheng Lin, Yao Lu*. Vortexing-generated high throughput single-cell droplets for facile analysis of multiplexed microRNA dynamic secretion. Biosensors and Bioelectronics, 2024, 257: 116303.
7. Huibing Li#, Xianming Liu#*, Fengjiao Zhu, Dachuan Ma, Chunyue Miao, Haoran Su,Jiu Deng, Haiyue Ye, Hongyu Dong, Xue Bai,Yong Luo,Bingcheng Lin, Tingjiao Liu*, Yao Lu*, Spatial barcoding-enabled highly multiplexed immunoassay with digital microfluidics. Biosensors and Bioelectronics, 2022, 215, 114557.
8. Shiqiang Yan, Shuting Wang, Zhujing Hao, Meimei Liu, Chunyue Miao, Md Fazle Alam, Ruihan Bai, Linmei Li, Yong Luo, Tingjiao Liu, Bingcheng Lin, Weijia Zhang*, Yao Lu*, Rapid prototyping of PDMS microdevices via mu PLAT on nonplanar surfaces with flexible hollow-out mask. Biofabrication, 2021, 13(3):035003.
9. Linmei Li, Weiwei Shi, Meimei Liu, Xue Bai, Yanting Sun, Xue Zhu, Haoran Su, Yahui Ji, Fengjiao Zhu, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, and Yao Lu*, Single-Cell Secretion Analysis in the Engineered Tumor Microenvironment Reveals Differential Modulation of Macrophage Immune Responses. Analytical Chemistry, 2021, 93(9): 4198–4207. (Featured in Analytical Chemistry website)
10. Yao Lu, Weiwei Shi, Lei Jiang, Jianhua Qin*, Bingcheng Lin*, Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay. Electrophoresis, 2009, 30(9):1497–1500. (≥800 citations)
