张晓雨，博士，助理研究员
邮箱：zhangxiaoyu@dicp.ac.cn
工作经历：
1）2025.04–至今 中国科学院大连化学物理研究所 助理研究员
2）2020.12–2025.04 中国科学院大连化学物理研究所 博士后
教育背景：
1）2015.09–2020.10 东北大学 生物医学工程 博士
2）2013.09–2015.07 东北大学 化学工程 硕士
3) 2009.09–2013.07 辽宁师范大学 化学 学士
研究方向：
1）蛋白翻译后修饰特异性富集材料的开发
2）功能性肽的筛选及小分子肽调控阿尔茨海默病的研究
代表性成果：
1.Xiaoyu Zhang,# Bowen Zhong,# Yue Sun, Dan Liu, Xiancheng Zhang, Dongdong Wang, Cunli Wang, Huiling Gao, Manli Zhong, Haijuan Qin, Yang Chen, Zhiying Yang, Yan Li, Haijie Wei, Xindi Yang, Yukui Zhang, Bo Jiang,* Lihua Zhang,* Guangyan Qing.* Deciphering the endogenous SUMO-1 landscape: a novel combinatorial peptide enrichment strategy for global profiling and disease association. Chem. Sci., 2025, 1: 2634-2647.
2. He Wang,# Xiaoyu Zhang,# Dongdong Wang, Qianqian Jiang, Yue Sun, Baofeng Zhao, Zhen Liang, Guangyan Qing,* Bo Jiang,* Lihua Zhang,* Yukui Zhang. Affinity peptide ligands: new tools for chasing non-canonical N-phosphoproteome, Chem. Sci., 2025, 16: 9290-9202.
3. Yue Qin,# Xiaoyu Zhang,# Yanling Song, Bowen Zhong, Lu Liu, Dongdong Wang, Yahui Zhang, Wenqi Lu, Xinjia Zhao, Zhiqi Jia, Minmin Li, Lihua Zhang,* Guangyan Qing.* A highly sensitive nanochannel device for the detection of SUMO1 peptides, Chem. Sci., 2023, 14: 8360–8368.
4. Mengdie Chen, Anying Zhu, Furong Zhu, Ziwen Lei, Tao Huang, Shengnan Du, Dongdong Wang, Xiaoyu Zhang,* Huan Min,* Yingqiu Qi,* Guangjun Nie. Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer, Nano Research, 2024, 17.
5. Yue Sun, Xue Wang, Xiaoyu Zhang,* Yan Li, Dongdong Wang, Feng Sun, Cunli Wang, Zhenqiang Shi, Xindi Yang, Zhiying Yang, Haijie Wei, Yanling Song,* Guangyan Qing.* Di-caffeoylquinic acid: a potential inhibitor for amyloid-beta aggregation. J. Nat. Med., 2024, 78: 1029-1043.
6. Xiancheng Zhang, Xiaoyu Zhang,* You Li, Manli Zhong, Pu Zhao, Chuang Guo, He Xu, Tao Wang, Huiling Gao.* Brain targeting and Aβ binding bifunctional nanoparticles inhibit amyloid protein aggregation in APP/PS1 transgenic mice. ACS Chem. Neurosci., 2021, 12: 2110-2121.
7. Xiaoyu Zhang, Manli Zhong, Pu Zhao, Xiancheng Zhang, You Li, Xuliang Wang, Jia Sun, Wang Lan, Hehong Sun, Zhanyou Wang,* Huiling Gao.* Screening a specific Zn(II)-binding peptide for improving the cognitive decline of Alzheimer's disease in APP/PS1 transgenic mice by inhibiting Zn2+-mediated amyloid protein aggregation and neurotoxicity. Biomater. Sci., 2019, 7: 5197-5210.
8. 卿光焱, 张晓雨, 王东东, 靶向SUMO化肽段的亲和多肽、SUMO 化肽段富集材料及制备方法和应用, 中国, 申请号：CN202411805020.6。
9. 张晓雨，高慧玲，钟曼丽，王占友，锌离子特异性结合肽及其组合物在预防或治疗阿尔茨海默症中的应用，中国，ZL201711374373.5。
