周晗，博士，副研究员

本草物质科学研究室/中药科学研究中心

电话：0411-84379539

邮箱：zhouhan418@dicp.ac.cn

学习和工作经历：

2019.4-2020.6Columbia University Medical Center访问学者

2018.6-至今 中国科学院大连化学物理研究所 副研究员

2016.9-2018.6中国科学院大连化学物理研究所 助理研究员

2014.2-2016.6Northeastern University, Center for Drug Discovery 博士后

2007.9-2014.1Northeastern University, Department of Chemistry and Chemical Biology博士

2003.9-2007.7中国科学技术大学化学系学士

研究方向：

1.基于GPCR的药物筛选与发现

2.药物-靶点的作用机理

3.天然产物质量控制

4.天然产物的抗肿瘤机理

代表性成果：

1.Han Zhou, Xingrong Peng, Tao Hou, Nan Zhao, Minghua Qiu, Xiuli Zhang and Xinmiao Liang (2020)Identification of novel phytocannabinoids from Ganoderma by label-freedynamic mass redistribution assay,Journal of Ethnopharmacology, 246, 112218, DOI:10.1016/j.jep.2019.112218

2.Yancheng Hu, Lin Yuan, Xiuli Zhang, Han Zhou, Pan Wang, Guangyi Li, Aiqin Wang, Yu Cong, Tao Zhang, Xinmiao Liang, Wei Li, Ning Li (2019) Production of 1,2-Cyclohexanedicarboxylates from Diacetone Alcohol and Fumarates,ACS Sustainable Chemistry & Engineering, 7, 2980-2988, DOI: 10.1021/acssuschemeng.8b04310

3.Michael S Malamas, Jimit Girish Raghav, Xiaoyu Ma, Chandrashekhar Honrao, JodiAnne T Wood, Othman Benchama, Han Zhou, Srikrishnan Mallipeddi, Alexandros Makriyannis (2018) Oximes short-acting CB1 receptor agonists,Bioorganic & medicinal chemistry, 26(18), 4963-4970, DOI: 10.1016/j.bmc.2018.08.003

4. Zhou, Han; Peng, Yan; Halikhedkar, Aneetha; Fan, Pusheng; Janero, David; Thakur, Ganesh; Mercier, Richard; Sun, Xin; Ma, Xiaoyu; Makriyannis, Alexandros (2017) Human Cannabinoid Receptor 2 Ligand-interaction Motif: Transmembrane Helix 2 Cysteine, C2.59(89), as Determinant of Classical Cannabinoid Agonist Activity and Binding Pose,ACS Chemical Neuroscience, 8(6), 1338-1347, DOI: 10.1021/acschemneuro.7b00003

5.Tian Hua, Kiran Vemuri, Mengchen Pu, Lu Qu, Gye Won Han, Yiran Wu, Suwen Zhao, Wenqing Shui, Shanshan Li, Anisha Korde, Robert B. Laprairie, Edward L. Stahl, Jo-Hao Ho, Nikolai Zvonok, Han Zhou, Irina Kufareva, Beili Wu, Qiang Zhao, Michael A. Hanson, Laura M. Bohn, Alexandros Makriyannis, Raymond C Stevens, and Zhi-Jie Liu (2016) Crystal Structure of the Human Cannabinoid Receptor CB1,Cell, 167(3):750-762.e14. DOI: 10.1016/j.cell.2016.10.004