王纪霞，博士，副研究员

本草物质科学研究室/中药科学研究中心

电话：0411-84379541

邮箱：jxwang@dicp.ac.cn

学习和工作经历：

2006.09-2010.07 山东师范大学，化学

2010.09-2015.09 中国科学院大连化学物理研究所，分析化学

2015.11-至今 中国科学院大连化学物理研究所，副研究员

研究方向：

探究GPCR靶点在神经、肿瘤及代谢性等重大疾病的调控机制

基于本草物质样品库的靶向先导活性分子发现与药效研究

基于临床有效方剂的分子机理研究

代表性成果：

[1] F. Xu, P. Wang, X. Zhang, T. Hou, L. Qu, C. Wang,J. Wang*, Y. Liu*, X. Liang*, Identification and target-pathway deconvolution of FFA4 agonists with 2 anti-diabetic activity from Arnebia euchroma (Royle) Johnst, Pharmacological Research, (2020) Accept.

[2]J. Wang, L. Chen, L. Qu, K. Li, Y. Zhao, Z. Wang, Y. Li, X. Zhang*, Y. Jin*, X. Liang*, Isolation and bioactive evaluation of flavonoid glycosides from Lobelia chinensis Lour using two-dimensional liquid chromatography combined with label-free cell phenotypic assays, Journal of chromatography A, 1601 (2019) 224-231.

[3]J. Wang, H. Qi, X. Zhang*, W. Si, F. Xu, T. Hou, H. Zhou, A. Wang, G. Li, Y. Liu, Y. Fang, H.-l. Piao*, X. Liang*, Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting beta-catenin signaling, Biomedicine & Pharmacotherapy, 108 (2018) 724-733.

[4] L. Wei,J. Wang, X. Zhang*, P. Wang, Y. Zhao, J. Li, T. Hou, L. Qu, L. Shi, X. Liang*, Y. Fang*, Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists, Journal of Medicinal Chemistry, 60 (2017) 362-372.

[5]X. Liang*,J. Wang, X. Zhang, Y. Fang, Label-Free Cell Phenotypic Identification of Active Compounds in Traditional Chinese Medicines, Label-Free Biosensor Methods in Drug Discovery, Y. Fang, Ed. (Springer New York, 2015), pp. 233-252.（专著）