王超然，博士，副研究员

本草物质科学研究室/中药科学研究中心

邮箱：wcrpj_505@dicp.ac.cn

学习和工作经历：

1、2003/09 -2007/06，浙江大学药学院，中药学，理学学士；

2、2007/09 -2013/01，保送中国科学院大连化学物理研究所，分析化学专业硕博连读，理学博士，导师：梁鑫淼研究员；

3、2013/03 -2015/07，中国科学院大连化学物理研究所，助理研究员；

4、2015/07-至今，中国科学院大连化学物理研究所，副研究员。 

研究方向：

聚焦中药先进制造技术的开发与应用集成，综合运用高效提取、膜分离、高效制备色谱、提取物中外源性污染物脱除等工艺技术开展中药组分制备研究，推动以组分中药为核心技术体系的中药大品种二次开发和创新中药研发，并推动相关技术在中药大健康产业中的应用。

代表性成果：

[1]Xiujie Guo, Zhenhua Gao, Jixia Wang, Zhimou Guo, Xiuli Zhang, Yanfang Liu, Lianzhi Wang,Chaoran Wang*, Xinmiao Liang*, Purification of tertiary and quaternary alkaloids from Rhizoma Corydalis using reversed-phase/weak cation-exchange mixed-mode class separationcombined with preparative C18 and silica based strong cation-exchangechromatography，Journal of Chromatography B，2019，1126-1127,

[2]Yan Zhang,Chaoran Wang (共同一作), Lien Wang, Gregory Scott Parks, Xiuli Zhang, Zhimou Guo, Yanxiong Ke, Kang-Wu Li, Mi Kyeong Kim, Benjamin Vo, Emiliana Borrelli, Guangbo Ge, Ling Yang, Zhiwei Wang, M Julia Garcia-Fuster, Z David Luo, Xinmiao Liang*, Olivier Civelli*, A Novel Analgesic Isolated from a Traditional Chinese Medicine, Current Biology, 2014，24(2), 117-123.

[3]Chaoran Wang, Zhimou Guo, Zhen Long, Xiuli Zhang*, Xinmiao Liang*, Overloading study of basic compounds with a positively charged C18 column in liquid chromatography, Journal of Chromatography A, 2013,1281, 60-66.

[4]Zhen Long,Chaoran Wang (共同一作), Zhimou Guo*, Xiuli Zhang, Lilly Nordahl, Xinmiao Liang*, Strong cation exchange column allow for symmetrical peak shape and increased sample loading in the separation of basic compounds, Journal of chromatography A, 2012,1256, 67-71.

[5]Chaoran Wang, Zhimou Guo, Jing Zhang, Jing Zeng, Xiuli Zhang, Xinmiao Liang*, High-performance purification of quaternary alkaloids from Corydalis yanhusuo WT Wang using a new polar-copolymerized stationary phase, Journal of separation science, 2011, 34(1), 53-58.

[6]Yan Zhang,Chaoran Wang (共同一作), Zhimou Guo, Xiuli Zhang, Zhiwei Wang, Xinmiao Liang*, Olivier Civelli*, Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography, Journal of Ethnopharmacology, 2014,155(3),1597-1602.