朴海龙，博士，研究员
本草物质科学研究室/中药科学研究中心
电话：0411-39787236
邮箱：hpiao@dicp.ac.cn
学习和工作经历：
1996.09-2000.07 沈阳农业大学 学士
2000.09-2003.02 韩国国立庆尚大学 硕士研究生
2003.03-2009.02 韩国国立庆尚大学 博士研究生
2009.03-2009.08 韩国国立庆尚大学 博士后
2009.09-2014.02 美国MD安德森癌症中心 博士后
2014.04-2015.06 中科院大连化学物理研究所 副研究员
2015.04-2016.03 中科院大连化学物理研究所研究员、中科院“百人计划”
2016.04-至今中科院大连化学物理研究所研究员、PI
研究方向：
癌症代谢、代谢稳态中生物分子时空分布及调控功能机制，多维生物分子网络的癌症系统生物学。
代表性成果：
1.Mitochondrial YBX1 promotes cancer cell metastasis by inhibiting pyruvate uptake. Chen H, Ling T, Chen D, Liu W, Qi H, Xia T, Liu X, Wang W, Guo X, Otkur W, Wang F, Xu Z, Martinou JC,Piao HL,Life Metabolism, Sep 7. 2023 doi.org/10.1093/lifemeta/load038.
2.Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate. Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY,Piao HL, Zhou J, Lin SC.Cell Res. 2023 Sep 19. doi: 10.1038/s41422-023-00874-4. Online ahead of print. PMID: 37726403.
3.Multidirectional characterization of cellular composition and spatial architecture in human multiple primary lung cancers. Wang Y, Chen D, Liu Y, Shi D, Duan C, Li J, Shi X, Zhang Y, Yu Z, Sun N, Wang W, Ma Y, Xu X, Otkur W, Liu X, Xia T, Qi H,Piao HL#, Liu HX#.Cell Death Dis.2023 Jul 25;14(7):462. doi: 10.1038/s41419-023-05992-w.
4.Dichloroacetic acid and rapamycin synergistically inhibit tumor progression. Chen H, Liang K, Hou C,Piao HL.J Zhejiang Univ Sci B.2023 May 15;24(5):397-405. doi: 10.1631/jzus.B2200356.
5.The roles of E3 ubiquitin ligases in cancer progression and targeted therapy. Sampson C, Wang Q, Otkur W, Zhao H, Lu Y#, Liu X#,Piao HL#.Clin Transl Med.2023Mar;13(3):e1204. doi: 10.1002/ctm2.1204.
6.Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts. Li T, Tan YT, Chen YX, Zheng XJ, Wang W, Liao K, Mo HY, Lin J, Yang W,Piao HL#,Xu RH#, Ju HQ#.Gut. 2023Mar;72(3):501-511. 2022
7.Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex.Xia T, Chen D, Liu X, Qi H, Wang W, Chen H, Ling T, Otkur W, Zhang CS, Kim J, Lin SC,Piao HL#.Cell Death Dis. 2022 Apr 29;13(4):414.
8.USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma. Ning Z, Guo X, Liu X, Lu C, Wang A, Wang X, Wang W, Chen H, Qin W, Liu X, Zhou L, Ma C, Du J, Lin Z, Luo H, Otkur W, Qi H, Chen D, Xia T, Liu J, Tan G#, Xu G#,Piao HL#.Nat Commun. 2022 Apr 21;13(1):2187.
9.Low-dose metformin targets the lysosomal AMPK pathway through PEN2.Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z,Piao HL, Deng X#, Zhang CS#, Lin SC#.Nature. 2022 Mar;603(7899):159-165.
10.Chen D, Zhang Y, Wang W, Chen H, Ling T, Yang R, Wang Y, Duan C, Liu Y, Guo X, Fang L, Liu W, Liu X, Liu J, Otkur W, Qi H, Liu X, Xia T, Liu HX,Piao HL#. Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network.Adv Sci (Weinh).2021 Jul 11:e2100311.
11.Liu X, Chen D, Chen H, Wang W, Liu Y, Wang Y, Duan C, Ning Z, Guo X, Otkur W, Liu J, Qi H, Liu X, Lin A, Xia T#, Liu HX#,Piao HL#. YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.Cancer Commun(Lond). 2021 Jul;41(7):576-595..
12.Zhang XX, Qi H, Liu YL, Yang SQ, Li P, Qiao Y, Zhang PY, Wen SH,Piao HL#, Han KL#. A fluorophore's electron-deficiency does matter in designing high-performance near-infrared fluorescent probes.Chem Sci. 2020 Sep 21;11(41):11205-11213.
13.Wang Y, Chen D, Liu Y, Zhang Y, Duan C, Otkur W, Chen H, Liu X, Xia T, Qi H,Piao HL#, Liu HX#. AQP3-mediated H2 O2 uptake inhibits LUAD autophagy by inactivating PTEN.Cancer Sci.2021 Jun 6. doi: 10.1111/cas.15008. (#Corresponding Author)
14.Zhang L, Zhu Z, Yan H, Wang W, Wu Z, Zhang F, Zhang Q, Shi G, Du J, Cai H, Zhang X, Hsu D, Gao P,Piao HL#, Chen G#, Bu P#. Creatine promotes cancer metastasis through activation of Smad2/3.Cell Metab. 2021 Jun 1;33(6):1111-1123.e4.
15.Wang Y, Qi H, Liu Y, Duan C, Liu X, Xia T, Chen D,Piao HL#, Liu HX#. The double-edged roles of ROS in cancer prevention and therapy.Theranostics. 2021 Mar 4;11(10):4839-4857.
16.Li M, Zhang CS, Feng JW, Wei X, Zhang C, Xie C, Wu Y, Hawley SA, Atrih A, Lamont DJ, Wang Z,Piao HL, Hardie DG#, Lin SC#. Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1. Cell Res. 2021 Apr;31(4):478-481.
17.Guo X, Wang A, Wang W, Wang Y, Chen H, Liu X, Xia T, Zhang A, Chen D, Qi H, Ling T,Piao HL#, Wang HJ#. HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer.Mol Oncol. 2021 Feb;15(2):642-656.
18.Wang W, Liu X, Chen H, Ling T, Xia T, Liu X, Liu J, Otkur W, Shi X, Qi H, Chen D,Piao HL#.Cholesterol as a functional metabolite cooperates with metadherin in cancer cells.Chinese Chemical Letters31(2020)1831–1834.
19.Zhang XX, Qi H, Lu MH, Yang SQ, Li P,Piao HL#, Han KL#. Semi-Quantitatively Designing Two-Photon High-Sensitive Fluorescent Probes for Glutathione S-Transferases with Negligible Background Noise.Research. 2020 Mar 18;2020:7043124.
20.Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X,Piao HL#, Liu H#.F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects.Theranostics. 2020; 10(9):4150-4167.
21.Chen D, Zhao X, Sui1 Z, Niu H, Chen L, Hu C, Xuan Q, Hou X, Zhang R, Zhou L, Li Y, Yuan H, Zhang Y, Wu J, Zhang L#, Wu R#,Piao HL#, Xu G#, Jia W#.A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases.Theranostics. 2020 Jan; 10(5): 2029-2046.
22.Chen D, Ning Z, Chen H, Lu C, Liu X, Xia T, Qi H, Wang W, Ling T, Guo X, Tekcham DS, Liu X, Liu J, Wang A, Yan Q, Liu JW#, Tan G#,Piao HL#. An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases.Oncogene. 2020 Jan;39 (3):587-602.
23.Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H,Piao HL#. A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.iScience. 2019 Jun 28;16:177-191.
24.Yan M, Qi H, Xia T, Zhao X, Wang W, Wang Z, Lu C, Ning Z, Chen H, Li T, Tekcham DS, Liu X, Liu J, Chen D, Liu X, Xu G#,Piao HL#. Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα.Metabolism.2019 Feb;91:18-29.
25.Piao HL, Yuan Y, Wang M, Sun Y, Liang H, Ma L. α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.Nat Cell Biol. 2014 Mar;16 (3):245-54.
